• 細胞生物學

• 國立陽明醫學院生物化學研究所博士
• 衛福部中國醫藥研究所副研究員
• 海洋大學生物科技研究所副教授、教授
• 海洋大學生物科技研究所所長
• 海洋大學生命科學系主任
• 高普考生物技術出題委員
• 海洋大學校長特助
• 海洋大學總務長

• 研究主題：

1. 膀胱癌和口腔癌之治療機制和新療法開發
2. 微生物活性物質表現，純化與鑑定
3. 褐藻糖膠的口腔癌和皮膚纖維化的可能應用
4. genome editing CRISPR/Cas9 技術開發和應用

• 實驗室常用技術：
  蛋白質工程，重組蛋白質表現，天然物純化，生物資訊，蛋白質體，生物技術，細胞培養，基因轉殖，HPLC ，流式細胞分析

1. Hsiao-Ying Chiu, Guang-Huan Sun, Shiow-Yi Chen, Hsiao-Hsien Wang, Ming-Yi Ho, Chia-Yi Chu, Wan-Lin Wu, Ren-Shiang Jhou, Yi-Lin Tsai, Rui-Ting Huang, Kuang-Hui Sun, Shye-Jye Tang*, "Pre-existing Fas ligand (FasL) in cancer cells elicits tumor-specific protective immunity, but delayed induction of FasL expression after inoculation facilitates tumor formation. Molecular Carcinogenesis, 2013 Sep;52(9):705-14. (Corresponding author) SCI=,"
2. Chang YC, Deng TS, Pang KL, Hsiao CJ, Chen YY, Tang SJ, Lee TH., "Polyketides from the littoral plant associated fungus Pseudallescheria boydii. J Nat Prod. 2013 Sep 27;76(9):1796-800.,"
3. Jwo SC, Tang SJ, Chen JR, Chiang KC, Huang TS, Chen HY., "A novel model for simultaneous study of neointestinal regeneration and intestinal adaptation. Wound Repair Regen. 2013 Mar-Apr;21(2):309-19.,"
4. Ho MY, Tang SJ, Chuang MJ, Cha TL, Li JY, Sun GH, Sun KH., "TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism. Mol Cancer Res. 2012 Aug;10(8):1109-19.,"
5. Chung LY, Tang SJ, Sun GH, Chou TY, Yeh TS, Yu SL, Sun KH., "Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. Clin Cancer Res. 2012 Aug 1;18(15):4037-47,"
6. Hsiao-Ying Chiu; Kuang-Huan Sun, PhD; Shiow-Yi Chen, PhD; Hsiao-Hsien Wang, MD, PhD; Ming-Yung Lee; Yu-Chi Tsou; Shyh-Chuan Jwo, MD; Guang-Hui Sun; Shye-Jy Tang*, "Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells. Cytokine, 2012 Aug;59(2):423-32. (Corresponding Author) SCI=3.537 44/134,"
7. Huang CS, Tang SJ, Chung LY, Yu CP, Ho JY, Cha TL, Hsieh CC, Wang HH, Sun GH, Sun KH., "Galectin-1 Upregulates CXCR4 to Promote Tumor Progression and Poor Outcome in Kidney Cancer. J Am Soc Nephrol. 2014 Feb 7.,"
8. Jwo SC, Chiu CH, Tang SJ, Hsieh MF., "Tubular scaffolds of gelatin and poly(ε-caprolactone)-block-poly(γ-glutamic acid) blending hydrogel for the proliferation of the primary intestinal smooth muscle cells of rats. Biomed Mater. 2013 Dec;8(6):065002.,"
9. Lee MY, Sun KH, Chiang CP, Huang CF, Sun GH, Tsou YC, Liu HY, Tang SJ., "Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90. Exp Biol Med (Maywood). 2014 Dec 16. pii: 1535370214554880,"
10. Galectin-3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with β-catenin. Oncotarget. 2014 Dec 31., "Chung LY, Tang SJ, Wu YC, Sun GH, Liu HY, Sun KH.,"
11. Hung, Kuo-Sheng; Chen, Shiow-Yi; Liu, Hsu-Feng; Tsai, Bing-Reui; Chen, Hung-Wei; Huang, Chin-Yen; Liao, Ji-Long; Sun, Kuang-Hui; Tang, Shye-Jye., "C-Terminal Region of Candida rugosa Lipases Affects Enzyme Activity and Interfacial Activation. Journal of Agricultural and Food Chemistry, 2011. 59(10):5396-401 (Corresponding author) SCI=2.46 10/118,"
12. Kuo-Sheng Hung, Shiu-Mei Liu, Wen-Shyong Tzou, Fu-Pang Lin, Chorng-Liang Pan, Tsuei-Yun Fang, Kuang-Hui Sun, Shye-Jye Tang., "Characterization of a novel GH10 thermostable, halophilic xylanase from the marine bacterium Thermoanaerobacterium saccharolyticum NTOU1. Process Biochemistry (2011) 46:1253-1263. (Corresponding author) SCI= 2.44 19/128,"
13. Hung KS, Liu SM, Fang TY, Tzou WS, Lin FP, Sun KH, Tang SJ., "Characterization of a salt-tolerant xylanase from Thermoanaerobacterium saccharolyticum NTOU1. Biotechnol Lett. 2011 Jul;33(7):1441-7. (Corresponding author) SCI= 1.626 90/152,"
14. Ho MY, Tang SJ, Sun KH, Yang W., "Immunotherapy for lung cancers. J Biomed Biotechnol. 2011;2011:250860. Epub 2011 Jan 24. SCI= 1.750 85/152,"
15. Song YC, Tang SJ, Lee TP, Hung WC, Lin SC, Tsai CY, Ng WV, Wu MF, Sun KH., "Reversing interleukin-2 inhibition mediated by anti-double-stranded DNA autoantibody ameliorates glomerulonephritis in MRL-lpr/lpr mice. Arthritis Rheum. 2010 Aug;62(8):2401-11 SCI=7.332 2/26,"
16. Ho MY, Tang SJ, Ng WV, Yang W, Leu SJ, Lin YC, Feng CK, Sung JS, Sun KH., "Nucleotide-binding domain of phosphoglycerate kinase 1 reduces tumor growth by suppressing COX-2 expression. Cancer Sci. 2010 Nov;101(11):2411-6. Sci=3.771 51/166,"
17. Lee TP, Tang SJ, Wu MF, Song YC, Yu CL, Sun KH J, "Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes. J. Autoimmun. 2010 Dec;35(4):358-67. Sci=7.231 13/128,"
18. Ming-Yi Ho , Shr-Jeng Jim Leu , Guang-Huan Sun , Mi-Hua Tao , Shye-Jye Tang, and Kuang-Hui Sun, "IL-27 Directly Restrains Lung Tumorigenicity by Suppressing Cyclooxygenase-2-Mediated Activities J. Immunology 2009 183: 6217-6226 (Corresponding author) Sci=5.646 18/128,"
19. Ren-Shiang Jhou, Kuang-Hui Sun, Guang-Huan Sun, Hsiao-Hsien Wang, Chung-I Chang, Hsiao-Chun Huang, Kuan-Ling Chang, and Shye-Jye Tang., "Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB. Cell Proliferation. 2009 42:141-149. Corresponding author Sci=2.917 90/162,"
20. Lee, Tai-Ping; Leu, Shr-Jeng Jim; Huang, Jason C.; Song, Ying-Chyi; Jhou, Ren-Shiang; Tang, Shye-Jye; Sun, Kuang-Hui., "Anti-ribosomal P autoantibody triggers IL-10 over-production via PI3K-dependent signaling pathways in LPS-activated macrophages. Immunology 2009 May;127(1):91-102. (Corresponding author) Sci=3.276 43/128,"
21. Shye-Jye Tang, Ming-Yi Ho, Han-Chieh Cho, Ying-Chun Lin, Guang-Huan Sun, Kwan-Hwa Chi, Yu-Shan Wang, Ren-Shiang Jhou, Winnie Yang, and Kuang-Hui Sun (2008), "Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo. Int J Cancer. 2008 Dec 15;123(12):2840-8 Sci=4.722 30/166,"
22. Chuang MJ, Sun KH, Tang SJ, Deng MW, Wu YH, Sung JS, Cha TL, Sun GH., "Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial- mesenchymal transition in renal cell carcinoma cells. (2008) Cancer Sci. 99:905-913. Sci=3.771 51/166,"
23. Song YC, Sun GH, Lee TP, Huang JC, Yu CL, Chen CH, Tang SJ, Sun KH., "Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalization via electrostatic interactions. Eur J Immunol. 2008 Nov; 38(11):3178-90. (Corresponding author) Sci=5.179 20/128,"
24. Ho MY, Sun GH, Leu SJ, Ka SM, Tang SJ, Sun KH., "Combination of FasL and GM-CSF confers synergistic antitumor immunity in an in vivo model of the murine Lewis lung carcinoma. (2008) Int J Cancer. 123: 123-133. (Corresponding author) Sci=4.722 30/166,"