黃志清老師

CHIH-CHING HUANG

PROFESSOR

Department of Bioscience and Biotechnology

National Taiwan Ocean University

Room 710, College of Humanities and Social Sciences Building

TEL: +886-2-2462-2192 Extension: #5517

Website: https://sites.google.com/site/drhuangccnanolab/

Email: huanging@ntou.edu.tw

At very small dimensions, materials can exhibit exotic physical properties markedly different from their bulk counterpart. These properties not only grant us a glimpse into the rules of physics allowing us to bridge the classical world and the quantum world; nanomaterials can also provide novel and often more efficient ways to perform tasks that used to be only achievable by biological methods.

The Huang research group is primarily interested in the application of nanotechnology in biotechnology. We have applied various nanomaterial (such as gold nanoparticle, carbon quantum dots, graphene oxide) and nanotechnology to address a variety of issues in various fields of biotechnology. Current research topics include:

Facile green synthesis of multifunctional nanomaterials from cheap, natural ingredients.
Development of biosensors for the detection of heavy metal ions, viruses, multidrug-resistant bacteria, protein biomarkers, and tumor cells.
Development of ECL reagent for signal development in immunoassays.
Development of nanodrugs such as anticoagulants, antiviral and antibacterial agents.
Development of cluster ion mass bioassay.

Recent Publications

Y.-J. Li, W.-J. Chiu, B. Unnikrishnan and C.-C. Huang*, 2014: Monitoring Thrombin Generation and Screening Anticoagulants through Pulse Laser-Induced Fragmentation of Biofunctional Nanogold on Cellulose Membranes ACS Appl. Mater. Interfaces, 6, 15253–15261.

W.-Y. Chen, H.-Y. Chang, J.-K. Lu, Y.-C. Huang, S. G. Harroun, Y.-T. Tseng, Y.-J. Li, C.-C. Huang* and H.-T. Chang*, 2015: Self-Assembly of Antimicrobial Peptides on Gold Nanodots: Against Multidrug-Resistant Bacteria and Wound-Healing Application Adv. Funct. Mater., 25, 7189–7199.

S.-S. Huang, S.-C. Wei, H.-T. Chang, H.-J. Lin and C.-C. Huang*, 2016: Gold Nanoparticles Modified with Self-Assembled Hybrid Monolayer of Triblock Aptamers as a Photoreversible Anticoagulant J. Control. Release, 221, 9–17.

P.-X. Lai, C,-W, Chen, S.-C. Wei, T.-Y. Lin, H.-J. Jian, I. P.-J. Lai, J.-Y. Mao, P.-H. Hsu, H.-J. Lin, W.-S. Tzou, S.-Y. Chen, S. G. Harroun, J.-Y. Lai* and C.-C. Huang*, 2016: Ultrastrong Trapping of VEGF by Graphene Oxide: Anti-angiogenesis Application Biomaterials, 109, 12–22.

H.-J. Jian, R.-S. Wu, T.-Y. Lin, Y.-J. Li, H.-J. Lin, S. G. Harroun, J.-Y. Lai* and C.-C. Huang*, 2017: Super-Cationic Carbon Quantum Dots Synthesized from Spermidine as an Eye Drop Formulation for Topical Treatment of Bacterial Keratitis ACS Nano, 11, 6703–6716.

C.-W. Lien, B. Unnikrishnan, S. G. Harroun, C.-M. Wang, J.-Y. Chang, H.-T. Chang* and C.-C. Huang*, 2018: Visual Detection of Cyanide Ions by Membrane-Based Nanozyme Assay Biosens. Bioelectron., 102, 510–517.

Y.-T. Tseng, H.-Y. Chang, S. G. Harroun, C.-W. Wu, S.-C. Wei, Z. Yuan, H.-L. Chou*, C.-H. Chen, C.-C. Huang* and H.-T Chang* Self-Assembled Chiral Gold Supramolecules with Efficient Laser Absorption for Enantiospecific Recognition of Carnitine. Anal. Chem. 2018, 90, 7283‒7291.

P.-X. Lai, J.-Y. Mao, B. Unnikrishnan, H.-W. Chu, C.-W. Wu, H.-T. Chang and C.-C. Huang* Self-Assembled, Bivalent Aptamers on Graphene Oxide as an Efficient Anticoagulant. Biomater. Sci. 2018, 6, 1882‒1891

A. Anand, B. Unnikrishnan, S.-C. Wei, C. P. Chou*, L.-Z. Zhang and C.-C. Huang*, 2019: Graphene Oxide and Carbon Dots as Broad-Spectrum Antimicrobial Agents – A Minireview Nanoscale Horiz., 4, 117–137.

Y.-J. Li, L.-J. Luo, S. G. Harroun, S.-C. Wei, B. Unnikrishnan, H.-T. Chang, Y.-F. Huang, J.-Y. Lai* and C.-C. Huang*, 2019: Synergistically Dual-Functional Nano Eye-Drops for Simultaneous Anti-Inflammatory and Anti-Oxidative Treatment of Dry Eye Disease Nanoscale, 11, 5580–5594.