Hsiu-Mei Lin

Professor

Department of Bioscience and Biotechnology

National Taiwan Ocean University

Room 302, General House II

TEL: +886-2-2462-2192 ext.5563

Website: http://lms.ls.ntou.edu.tw/board.php?courseID=89&f=doc&cid=13036

HM.Lin lab has the profession in the research fields of nano biotechnology, biomedical materials, intelligent drug delivery, nano drug delivery, biomedical nano images, green chemistry, material chemistry, phosphor, marine active substances, marine biotechnology development, algae extraction.

Intelligent drug delivery system, mesoporous silica nanoparticles (MSNs) is what we use for research. MSNs owns attractive features such as ordered mesoporous arrangement, high specific surface area, large pore volume, adjustable pore size and modifiable surface. With these advantages we can mix MSNs with optical and magnetic elements to empower MSNs with tracking ability, and after modify MSNs with targeting and release control molecules, we then accomplish a new non-invasive intelligent drug delivery system with tracking and multifunction.

About the multifunctional bone repair system, mesoporous bioactive glass (MBG) is the material we use for this researching field. MBG is made of calcium, phosphorus, it is a material for bone repair. Inherit the advantages of mesoporous silica materials, MBG can be further process to become a multi-functional deliverable drug bone repair system with specific targeted drug treatments and non-invasive detection tracking.

Functional materials for biological resources/waste conversion, common substances around the life, such as the shell is rich in high proportion of calcium carbonate, the special pattern of silica pore structure of the algae itself, and the high content of silica in the rice husk, which can be further modified by the purification process. Functionally recycled materials give value to resources that can be used more efficiently.

Recently, we are working on the combination of nanoparticles and algae polysaccharides. Extracted algae polysaccharide was identified and analyze its quantity and quality. Hopefully we can combine those polysaccharides with MSNs for further medical research.

Experimental organisms like cultured cells, algae, nude mouse and zebra fish is the main experimental organism used in this laboratory.

Common techniques in the laboratory:

The technique and instrument used in this lab are: XRD, BET, TGA, FT-IR, SEM, TEM, SQUID, ICP, Cell culture, UV-vis, PL/PLE, Confocal/IVIS, MRI and HPLC.

Chemical engineering, nanomaterials, drug carriers, green energy technology, biomedical materials, optoelectronic technology is our connection with future industry. We are very welcome to whom is interested in our laboratory, it is our pleasure for you to come, discuss and understand more about our laboratory work or even join us in the future.

1. 林秀美、張宗元、游子毅, "一種以貝殼做為基礎原料所製成之磷酸鈣材料及製造該磷酸鈣材料的方法," 發明第I448419號, 專利期限: 2014-2032

1.	Shiao-Wen Tsai, Xin-Wen Yu, Pai-An Hwang, Sheng-Siang Huang, Hsiu-Mei Lin, Yu-Wei Hsu, and Fu-Yin Hsu, "Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofiber with a Mesoporous Structure as Drug Delivery Carriers," Pharmaceutics, Dec, 2018.
2.	Wei-Ju Lin, Yu-Ming Liao, Hsia-Yu Lin, Haider Golam, Shih-Yao Lin, Wei-Cheng Liao, Ruei-Ti Wei, Perumal Packiyara, Tsung-Yuan Chang, Chang-Yang Tseng, Yan-Shawn Lo, Hsiu-Mei Lin, Tung-Wei Shih, Jiang-Shiou Hwang, Tai-Yuan Lin and Yang-Fang Chen, "All-marine based random lasers," Organic Electronics, Nov, 2018.
3.	Chih-Min Wang, Ming-Feng Pan, Yong-Jie Lin, Mei-Ying Chung, Yuh-Sheng Wen, Chang Yung, Hsiu-Mei Lin, and Hsu Todd, "A Series of Organic-Inorganic Hybrid Zinc Phosphites Containing Extra-Large Channels," Inorganic Chemistry, Mar, 2018.
4.	Kai-Chi Chang, Chan-Yu Chen, Tzu-Pin Lin, Po-Jen Ku, Chun-Lin Chen, Chih-Min Wang, Hsiu-Mei Lin, Mei-Chun Tseng, Singh Ashoutosh, and Shih-Sheng Sun "Platinum(II)-directed Self-assembly Loop Complexes for Anion Recognition and Sensing," Inorganic Chemistry, Jan, 2018.
5.	Shu-Ming Hsiao, Bo-Yan Peng, Ying-Shun Tseng, Hsin-Tao Liu, Chih-Hwa Chen, and Hsiu-Mei Lin, "Preparation and characterization of multifunctional mesoporous silica nanoparticles for dual magnetic resonance and fluorescence imaging in targeted cancer therapy," Microporous and Mesoporous Materials, Sep, 2017.
6.	Chih-Min Wang, Ming-Feng Pan, Yen-Chieh Chen, Hsiu-Mei Lin, Mei-Ying Chung, Yuh-Sheng Wen, and Kwang-Hwa Lii, "Two Polymorphs of an Organic Zincophosphate Incorporating a Terephthalate Bridging Ligand in an Unusual Bonding Mode," Microporous and Mesoporous Materials, Jul, 2017.
7.	Shiow-Yi Chen, Po-Fong Chou, Wai-Kong Chan, and Hsiu-Mei Lin, "Preparation and characterization of mesoporous bioactive glass from agricultural waste rice husk for targeted anticancer drug delivery," Ceramics International, Feb, 2017.
8.	Tsung-Yuan Chang, Chih-Min Wang, Tai-Yuan Lin, and Hsiu-Mei Lin, "Conversion of Biowaste Asian Hard Clam (Meretrix lusoria) Shells into White-Emitting Phosphors for Use in Neutral White LEDs," Materials, Dec, 2016.
9.	Wang, C. M.; Lee, L. W.; Chang, T. Y.; Fan, B. L.; Wang, C. L., "New 3D Tubular Porous Structure of an Organic–Zincophosphite Framework with Interesting Gas Adsorption and Luminescence Properties," Chemistry-a European Journal, Oct, 2016.
10.	Tsung-Yuan Chang,Zhao-Nan Yan, Chun-Chi Wang, Hsing-Chun Li,Hsiu-Mei Lin and Chih-Min Wang, "New hybrid organic-zincophosphate frameworks:single-crystal-to-single-crystal structural transformation and remarkable thermal and chemical stabilities," Dalton Transactions, May, 2016.
11.	Chih-Min Wang, Tsung-Yuan Chang, Li-Wei Lee, Hsiu-Mei Lin, Kuang-Lieh Lu and Kwang-Hwa Lii, "The first zinc phosphite with remarkable structural and functional transformations," Chemical Communications, Sep, 2015.
12.	Fu-Yin Hsu, Ru-Chun Weng, Hsiu-Mei Lin, Yi-Hsuan Lin, Meng-Ru Lu, Jing-Lun Yu, Hsien-Wen Hsu, "A biomimetic extracellular matrix composed of mesoporous bioactive glass as a bone graft material," Microporous and Mesoporous Materials, Aug, 2015.
13.	Yu-Chia Chen, Cih-Su Wang, Tsung-Yuan Chang, Tai-Yuan Lin, Hsiu-Mei Lin and Yang-Fang Chen, "Ultraviolet and visible random lasers assisted by diatom frustules," Optics Express, Jun, 2015.
14.	Yu-Chun Chen, Hsiao-Ya Huang, Hsiu-Mei Lin, Fu-Yin Hsu, Yu-Ping Su and Deng-Fwu Hwang, "Biomaterial availability of magnesium substituted beta-tricalcium phosphate converted from sea urchin Tripneustes gratilla shell," Journal of the Ceramic Society of Japan, Jun, 2015.
15.	Chiang-Ting Chen, Fang-Chi Hsu, Jeng-Yeh Huang, Chi-Yuan Chang, Tsung-Yuan Chang, Hsiu-Mei Lin, Tai-Yuan Linc and Yang-Fang Chen, "Effects of a thermally stable chlorophyll extract from diatom algae on surface textured Si solar cells," Rsc Advances, Apr, 2015.
16.	Fu-Yin Hsu, Meng-Ru Lu, Ru-Chun Weng and Hsiu-Mei Lin, "Hierarchically biomimetic scaffold of a collagen–mesoporous bioactive glass nanofiber," Biomedical Materials, Mar, 2015.
17.	Ming-Hsien Chan and Hsiu-Mei Lin, "Preparation and Identification of Multifunctional Mesoporous Silica Nanoparticles for In Vitro and In Vivo Dual-Mode Imaging, Theranostics, and Targeted Tracking," Biomaterials, Jan, 2015.
18.	Wang, C. M.; Lee, L. W.; Chang, T. Y.; Chen, Y. C.; Lin, H. M.; Lu, K. L.; Lii, K. H., "Organic-Inorganic Hybrid Zinc Phosphate with 28-Ring Channels," Chemistry-A European Journal, Jan, 2015.
19.	Chan, M.-H. and Lin, H.-M., "Preparation and Identification of Multifunctional Mesoporous Silica Nanoparticles for In Vitro and In Vivo Dual-Mode Imaging, Theranostics, and Targeted Tracking," Biomaterials, Impact Factor: 8.312, Dec, 2014.
20.	Yu, Y.-H.; Chan, C.-C.; Lai, Y.-C.; Lin, Y.-Y.; Huang, Y.-C.; Chi, W.-F.; Kuo, C.-W.; Lin, H.-M. and Chen, P.-C., "Biocompatible electrospinning poly (vinyl alcohol) nanofibres embedded with graphene-based derivatives with enhanced conductivity, mechanical strength and thermal stability," RSC Advances, Impact Factor: 3.708, 2014.
21.	Huang, C.-Y.; Lee, Y.-J.; Lin, T.-Y.; Chang, S.-L.; Lian, J.-T.; Lin, H.-M.; Chen, N.-C. and Yang, Y.-J., "Direct formation of InN-codoped p-ZnO/n-GaN heterojunction diode by solgel spincoating scheme," Optics Letters, Impact Factor: 3.179, 2014.
22.	Periasamy, A.-P.; Liu, J.-F.; Lin, H.-M. and Chang, H.-T., "Synthesis of copper nanowire decorated reduced graphene oxide for electro-oxidation of methanol," Journal of Materials Chemistry A, Impact Factor: 6.626, 2013.
23.	Lin, H.-M.; Lin, H.-Y. and Chan, M.-H., "Preparation, characterization, and in vitro evaluation of folate-modified mesoporous bioactive glass for targeted anticancer drug carriers," Journal of Materials Chemistry B, Impact Factor: 6.626, 2013.
24.	Lin, H.-M.; Lin, Y.-H. and Hsu, F.-Y., "Preparation and characterization of mesoporous bioactive glass/polycaprolactone nanofibrous matrix for bone tissues engineering," Journal of Materials Science-Materials, Impact Factor: 2.141, 2012.
25.	Hwang, J.-S.; Kao, M.-C.; Shiu, J.-M.; Fan, C.-N.; Ye, S.-C.; Yu, W.-S.; Lin, H.-M.; Lin, T.-Y.; Chattopadhyay, S.; Chen, L.-C. and Chen, K.-H., "Photocurrent Mapping in High Efficiency Radial P-N Junction Silicon Nanowire Solar Cells Using Atomic Force Microscopy," Journal of Physical Chemistry C, Impact Factor: 4.805, 2011.
26.	Lin, H.-M.; Wang, W.-K.; Hsiung, P.-A. and Shyu, S.-G., "Light-sensitive intelligent drug delivery systems of coumarin-modified mesoporous bioactive glass," Acta Biomaterialia, Impact Factor: 4.824, 2010.
27.	Chang, J.-R.; Lin, H.-M.; Cheng, S.-W.; Tseng, C.-K.; Tzou D.-L. and Shyu, S.-G., "EXAFS investigation of the morphology of immobilized Rh(PPh3)(3)Cl on phosphinated MCM-41," Journal of Molecular Catalysis A-Chemical, Impact Factor: 2.872, 2010.
28.	Lin, R.; Horng, H.-C.; Lin, H.-M.; Lin, S.-Y.; Hon, Y.-S. and Chow, T.-J., "2-Amino-3-naphthylacrylonitrile Derivatives as Green Luminance Dyes," Journal of the Chinese Chemical Society, Impact Factor: 0.718, 2010.
29	Lin, H.-M. and Chang T.-Y., "A 3-D porous metal-organic framework with a bcu topology constructed from 48-membered tetraicosanuclear metallamacrocycle based on in situ ligand synthesis," Crystal Growth & Design, Impact Factor: 4.215, 2009.

Hsiu-Mei Lin

Publications:

Patents: