Department of Bioscience and Biotechnology

National Taiwan Ocean University

Room 302A, General House II

TEL: +886-2-2462-2192 Extension: #5522

Email: wstzou@ntou.edu.tw

We employed the seemingly unlimited computation power of CPU and GPU to tackle the interesting and important questions of human health. First is the intriguing allosteric regulation of protein function. We developed and also applied various algorithms to delineate the communication pathways that enables the allosteric regulation. The current focus is on the human serum albumin and the extracellular domain of SCF-KIT complex. Second is to discover the linkage between the human genotype human and creativity. We employed SNP array to find out the correlation between locus and the traits of high creativity.


1.     Jing Hou, Heping Zheng*, Wen‐Shyong Tzou, David R. Cooper, Maksymilian Chruszcz, Mahendra D. Chordia, Keehwan Kwon, Marek Grabowski, Wladek Minor*, "Differences in substrate specificity of V. cholerae FabH enzymes suggest new approaches for the development of novel antibiotics and biofuels.," FEBS J. 2018 Aug;285(15):2900-2921, Aug, 2018.

2.     Hung KS, Hsiao CC, Pai TW*, Hu CH, Tzou WS, Wang WD, Chen YR, "Functional enrichment analysis based on long noncoding RNA associations.," BMC Syst Biol. 2018 Apr 24;12(Suppl 4):45., Apr, 2018.

3.     Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang*, "Ultrastrong Trapping of VEGF by Graphene Oxide: Anti-angiogenesis Application," Biomaterials. 2016 109:12-22., 2016.

4.     Chi-Fu Chou, Han-Jia Lin, Chih-Yu Tsai, Tzung-Yi Lin, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Tun-Wen Pai, Chin-Hwa Hu, and Wen-Shyong Tzou*., "Hypoxia-inducible factor 2-alpha participates in the regulation of intersegmental vessels angiogenesis and neuromast deposition.," Journal of Marine Science and Technology, Vol. 24, No. 2, pp. 347-358, 2015.

5.     Wen‑Sing Liang, Tsuei‑Yun Fang, Hong‑Ting Lin, Tristan C. Liu, Wen‑Jung Lu, Wen‑Shyong Tzou, Shye‑Jye Tang, Fu‑Pang Lin, Shiu‑Mei Liu, Chorng‑Liang Pan*, "Cloning, expression, and characterization of Pseudomonas vesicularis MA103 β‑1,3‑xylanase in Escherichia coli ClearColi BL21(DE3)," Fish Sci (2015) 81:1135–1143, 2015.

6.     Wen-Shyong Tzou*, Ying-Tsang Lo, Tun-Wen Pai, Chin-Hwa Hu, Chung-Hao Li., "Stochastic Simulation of Notch Signaling Reveals Novel Factors that Mediate the Differentiation of Neural Stem Cells," Journal of Computational Biology, 21(7):1-20., 2014.

7.     Wen-Shyong Tzou*, Ying Chu, Tzung-Yi Lin, Chin-Hwa Hu, Tun-Wen Pai, Hsin-Fu Liu, Han-Jia Lin, Ildeofonso Cases, Ana Rojas, Mayka Sanchez, Zong-Ye You, Ming-Wei Hsu., "Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom.," PLoS One, 9(1): e86718, 2014., 2014.

8.     Xing-Guang Hung, Wen-Chi Tseng, Shiu-Mei Liu, Wen-Shyong Tzou, Tsuei-Yun Fang*, "Characterization of a thermophilic l-arabinose isomerase from Characterization of a thermophilic l-arabinose isomerase from thermoanaerobacterium saccharolyticum NTOU1.," Biochemical Engineering Journal, 83:121–128, 2014.

9.     Tzung-Yi Lin, Chi-Fu Chou, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li,Jen-Leih Wu, Han-Jia Lin, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou*, "Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.," PLoS One, 9(7): e101980, 2014.

10.   Chien-Ming Chen, Yu-Lun Lu, Chi-Pong Sio, Guan-Chung Wu, Wen-Shyong Tzou, Tun-Wen Pai*, "Gene Ontology based housekeeping gene selection for RNA-seq normalization," Methods, 67(3): 354-363, 2014.

11.   Chien-Ming Chen, Tun-Wen Pai*, Chia-Sheng Chuang, Jhen-Li Huang, Wen-Shyong Tzou, Chin-Hua Hu, "Identifying significant associations of orthologous simple sequence repeats with gene ontologies," International Journal of Data Mining and Bioinformatics, 9(1):37-51, 2014.

12.   C.-T. Chang, H.-Y. Chung, H.-T. Su, H.-P. Tseng, W.-S. Tzou, C.-H. Hu*., "Regulation of zebrafish CYP3A65 transcription by AHR2," Toxicology and Applied Pharmacology, 270(2):174-184, 2013.

13.   H.-Y. Chung, C.-T. Chang, H.-W. Young, S. P. Hu, W.-S. Tzou, C.-H. Hu*., "Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway," Neurotoxicology and Teratology, 38:92-103, 2013.

14.   Ying-Tsang Lo, Hsin-Wei Wang, Tun-Wen Pai*, Wen-Shoung Tzou, Hui-Huang Hsu, Hao-Teng Chang., "Protein-ligand binding region prediction (PLB-SAVE) based on geometric features and CUDA acceleration," BMC Bioinformatics, 14 Suppl 4:S4, 2013.

15.   Wei-Hung Chang, Chi-Ying Lee, Chih-Yu Lin, Wei-Yun Chen, Meng-Chieh Chen, Wen-Shyong Tzou, and Yet-Ran Chen*., "UniQua: A Universal Signal Processor for MS-Based Qualitative and Quantitative Proteomics Applications," Analytical Chemistry, 85(2):890-897, 2013.

16.   Fu-Pang Lin*, Hsiu-Yen Ma, Hui-Ju Lin, Shiu-Mei Liu, Wen-Shyong Tzou, "Biochemical characterization of two truncated forms of amylopullulanase from Thermoanaerobacterium saccharolyticum NTOU1 to identify its enzymatically active region," Applied Biochemistry and Biotechnology, 165(3-4):1047-1056, 2011.

17.   C.-S. Chuang, T.-W. Pai*, H.-C. Hu, W.-S. Tzou, M.-D.-T. Chang, H.-T. Chang, C.-C. Chen, "Functional pathway mapping analysis for hypoxia-inducible factors," BMC Systems Biology, 5 Suppl 1:S3, 2011.

18.   C.-Y. Ko, M.-Y. Tsai, W.-F. Tseng, C.-H. Cheng, C.-R. Huang, J.-S. Wu, H.-Y. Chung, C.-S. Hsieh, C.-K. Sun, S.-P. Hwang, C.-H. Yuh, C.-J. Huang, T.-W. Pai, W.-S. Tzou and C.-H. Hu*., "Integration of CNS survival and differentiation by HIF2α," Cell Death and Differentiation, 18(11):1757–1770, 2011.

19.   K.-S. Hung, S.-M. Liu, T.-Y. Fang, W.-S. Tzou, F.-P. Lin, K.-H. Sun and S.-J. Tang*., "Characterization of a salt-tolerant xylanase from Thermoanaerobacterium saccharolyticum NTOU1," Biotechnology Letters, 33(7):1441-1447, 2011.

20.   W.-P. Lee and W.-S. Tzou*., "Fast Revelation of the Motif Mode for a Yeast Protein Interaction Network Through Intelligent Agent-Based Distributed Computing," Protein and Peptide Letters, 17(9):1091-1101, 2010.

21.   C.-J. Lin, W.-C. Tseng, T.-H. Lin, S.-M. Liu, W.-S. Tzou and T.-Y. Fang*., "Characterization of a Thermophilic l-Rhamnose Isomerase from Thermoanaerobacterium saccharolyticum NTOU1," Journal of Agricultural and Food Chemistry, 58(19):10431–10436, 2010.

22.   C.-M. Chen, C.-C. Chen, T.-H. Shih, T.-W. Pai*, H.-C. Hu, and W.-S. Tzou., "Efficient algorithms for identifying orthologous simple sequence repeats of disease genes," Journal of Systems Science and Complexity, 23:906-916, 2010.

23.   W.-S. Tzou, W.-P. Lee* and B.-C. Jeng., "Exploiting knowledge ontology and software agents for PPI network analysis," Expert Systems with Applications, 36(10):12605–12612, 2009.

24.   W.-P. Lee and W.-S. Tzou*., "Computational methods for discovering gene networks from expression data," Briefings in Bioinformatics, 10(4):408-423, 2009.

25.   Tun-Wen Pai*, Chien-Ming Chen, Meng-Chang Hsiao, Ronshan Cheng, Wen-Shyong Tzou, Chin-Hua Hu., "An online conserved SSR discovery through cross-species comparison," Advances and Applications in Bioinformatics and Chemistry, 2:23-35, 2009.

26.   Yin HC, Tseng HP, Chung HY, Ko CY, Tzou WS, Buhler DR, Hu CH*, "Influence of TCDD on zebrafish CYP1B1 transcription during development.," Toxicol Sci. 2008 May;103(1):158-68., 2008.

27.   Pai TW*, Chang MD, Tzou WS, Su BH, Wu PC, Chang HT, Chou WI., "REMUS: a tool for identification of unique peptide segments as epitopes.," Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W198-201., 2006.

28.   Lee WP, Jeng BC, Pai TW, Tsai CP, Yu CY, Tzou WS*, "Differential evolutionary conservation of motif modes in the yeast protein interaction network.," BMC Genomics. 2006 Apr 25;7:89., 2006.

*: corresponding author


Google scholar: https://scholar.google.com/citations?user=dyaSziwAAAAJ&hl=en

Research gate: https://www.researchgate.net/profile/Wen_Shyong_Tzou