Research
The graduate program of the Department of Bioscience and Biotechnology offers three specializations: Biomedical Science, Chemistry, and Net-Zero Carbon Emissions. Our graduate training emphasizes advanced technologies and interdisciplinary learning. Department of Bioscience and Biotechnology has a total of 12 full-time faculty members, with research areas outlined below:
Genetic Engineering Laboratory
Focused on developing algae restoration technology and its carbon capture applications, especially investigating the potential role of fucoidan in cancer stem cells. By studying the properties of Fucoidan, we aim to discover effective treatments and develop novel therapies for cancers such as bladder cancer, oral cancer, and osteosarcoma. The lab actively employs CRISPR/Cas9 gene-editing technology to enhance the precision and efficacy of cancer treatments and also emphasizes enzyme protein engineering for cancer therapy and gene technology innovations. These efforts aim to broaden biomedical applications and provide new ideas for future cancer treatments, ultimately improving overall healthcare.
Shye-Jye Tang
Immuno-Oncology and Virology Laboratory
Specializing in the molecular regulation mechanisms and immune responses of novel nanomedicine against triple-negative breast cancer, dengue virus, and influenza virus. For triple-negative breast cancer, we aim to enhance therapeutic effects and reduce side effects using innovative nanomedicines. In virology research, we focus on inhibiting viral replication and improving prevention. These research findings will contribute to advancing translational medicine and benefiting patients.
Shiow-Yi Chen
Cardiovascular Biomedical Research Laboratory
Dedicated to cardiovascular biomedical research, focusing on mechanisms of cardiovascular protection and disease pathology. Using in vitro cell models to simulate vascular lesion environments, we investigate disease mechanisms and develop therapeutic approaches. Collaborations with physicians from National Taiwan University Hospital enable us to conduct clinical trials and develop novel diagnostic methods and treatment strategies. Through these studies, we aim to provide innovative solutions for diagnosing and treating cardiovascular diseases, addressing their status as the leading cause of death in Taiwan.
Ding-Yu Lee
Microbiology and Translational Medicine Laboratory
Focused on studying bacterial pathogenic mechanisms and genes, exploring the interactions between microorganisms and host cells. We develop alternative and innovative antibacterial substances targeting drug-resistant bacteria and conduct research under the "One Health" framework to study antibiotic-resistant bacteria from environmental and food sources. The lab also investigates the role of gut microbiota in infectious diseases, aiming to provide new insights for treatment and public health. Our research enhances our understanding of bacterial infections and contributes to developing effective therapies to promote human health and disease prevention.
Chun-Ru Hsu
Biomass Mass Spectrometry Laboratory
Specializing in the development and application of mass spectrometry techniques to study fine and precise molecular interactions. Research directions include developing mass spectrometry methods to identify interaction sites between aptamers and proteins, studying genetic and proteomic changes in algae under ocean acidification, and advancing acetyl-proteomics. Additionally, the lab uses photoactivated crosslinking technology combined with mass spectrometry to analyze peptide-protein interactions, providing innovative knowledge for biotechnology and medical applications.
Pang-Hung Hsu
Interdisciplinary Innovation Laboratory
Pioneering molecular genetics and gene-editing research in diatoms, being the first in Taiwan to establish diatom genetic engineering techniques and globally leading the development of molecular herbal medicine as antibiotic substitutes in aquaculture. The lab explores synthetic biology to produce polyamines from algae, studies their metabolism and applications, and focuses on net-zero carbon aquaculture solutions. Innovative systems like algal-bacterial symbiotic flocs reduce carbon emissions and enhance disease resistance and productivity. Collaborations with industry aim to develop novel enzymes, reagents, and sustainable solutions for medical and environmental applications.
Han-Jia Lin
Marine Natural Bioactive Substances Laboratory
Focused on studying large brown algae for bioactive compounds and metabolomics, with applications in biomaterial development. Utilizing advanced extraction and fermentation techniques, the lab aims to transfer technology to industry. By leveraging proteomics and big data, we study bioactive substances in brown algae and validate their efficacy through animal studies. Fermentation technology is also explored for medical device applications. These studies aim for breakthroughs in biomedicine and environmental sustainability, contributing to human health and ecological quality.
Pai-An Hwang
Biomedical Materials and Tissue Engineering Laboratory
Focused on developing 3D scaffolds mimicking extracellular matrix structures for tissue engineering applications. The lab explores functional biomedical composite scaffolds to promote cell growth and tissue regeneration while investigating the potential of marine materials for biomedical applications. These studies aim to enhance the functionality and applicability of biomedical materials and advance medical technologies.
Fu-Yin Hsu
Multifunctional Smart Nanomaterials Laboratory
Specializing in multifunctional smart nanomaterials for applications in nanobiotechnology, intelligent drug delivery, and biomedical materials. Research includes innovative nanomedicine delivery systems, biomedical imaging technologies, and marine-derived bioactive substances. The lab also explores applications in cosmetics, aiming to achieve breakthroughs in health and beauty through sustainable development.
Hsiu-Mei Lin
Self-Assembled Materials for Nanobiomedical Applications Laboratory
Focused on developing self-assembled carbon and transition metal carbide nanomaterials for biomedical and green energy applications. The lab works on preparing biocompatible soft carbon materials for uses such as anticoagulation, anti-angiogenesis, antimicrobial, antiviral, and immunomodulation. These materials are applied in drug delivery, nanozymes, and nanomedicine, promoting the development of biomimetic biomedical materials for clinical applications.
Chih-Ching Huang
Novel Crystalline Material Synthesis and Applications Laboratory
Innovates in "chemistry + materials" for sustainable environments and food safety. The lab develops functional crystalline materials for energy storage (H₂ and CO₂), environmental monitoring, and food safety detection (e.g., heavy metals and biogenic amines). By driving interdisciplinary research, these materials aim to support sustainability and address key environmental challenges.
Chih-Min Wang
Translational Genomic Medicine Laboratory
Specializing in genomic analysis and AI technologies to study cancer mutation burden pathways and identify biomarkers and key genes for common cancers in Taiwan. Research includes protein structure simulation and engineering to develop potential plastic-degrading enzymes, contributing to environmental sustainability. The lab's interdisciplinary research aims to make breakthroughs in genomic medicine and protein applications, benefiting medicine and environmental science.
Wen-Shyong Tzou
Update date:2024/12/07