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許邦弘 教授

<div><strong>姓     名:</strong>許邦弘 老師實驗室</div>

<div><strong>英 文 姓 名:</strong>Pang-Hung Hsu</div>

<div><strong>研 究 專 長:</strong>質譜學、蛋白質體學、生物分析化學</div>

<div><strong>電 子 信 箱:</strong><a href="mailto:phsu@ntou.edu.tw"><span style="color:#0066cc;">phsu@ntou.edu.tw</span></a></div>

<div><strong>研究室位置:</strong>海事大樓丙棟111研究室</div>

<div><strong>研究室電話:</strong>2462-2192 ext. 5567; 5568</div>

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<div><strong>主要授課課程:</strong></div>

<ul>
<li style="list-style: inherit;">有機化學</li>
<li style="list-style: inherit;">分析化學</li>
<li style="list-style: inherit;">儀器分析</li>
</ul>

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<div><strong>學經歷:</strong></div>

<ul>
<li style="list-style: inherit;">美國俄亥俄州立大學化學博士</li>
</ul>

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<div><strong>研究項目簡介:</strong></div>

<ol>
<li>開發質譜學方法以鑑定適體與蛋白質之交互作用區域</li>
<li>從基因蛋白體學剖析藻類在海洋酸化下所受之影響</li>
<li>乙醯化蛋白體學之方法開發</li>
<li>應用光活化交聯鍵結與質譜分析技術研究胜肽與蛋白質交互作用</li>
</ol>

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<div><strong>期刊論文:</strong><a href="https://arspb.nstc.gov.tw/NSCWebFront/modules/talentSearch/talentSearch.do?action=initRsm05&amp;rsNo=20233b6b44e341d2aba45247640e8a87&amp;LANG=chi" target="_blank" title="https://arspb.nstc.gov.tw/NSCWebFront/modules/talentSearch/talentSearch.do?action=initRsm05&amp;rsNo=20233b6b44e341d2aba45247640e8a87&amp;LANG=chi"><span style="color: rgb(0, 102, 204);">科技部研究人才查詢-著作目錄</span></a></div>

<ol>
<li>Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang, &quot;Ultrastrong trapping of VEGF by graphene oxide: Anti-angiogenesis application,&quot; Biomaterials, Dec, 2016.</li>
<li>Hsueh-Tzu Shih, Wei-Yu Chen, Kwei-Yan Liu, Zong-Siou Shih, Yi-Jyun Chen, Paul-Chen Hsieh, Kuan-Lin Kuo, Kuo-How Huang, Pang-Hung Hsu, Ya-Wen Liu, Shih-Peng Chan, Hsiu-Hsiang Lee, Yu-Chen Tsai, June-Tai Wu, &quot;dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations,&quot; PLoS Genetics, Sep, 2016.</li>
<li>Lung-Hsiang Peng, Binesh Unnikrishnan, Chi-Yu Shih, Tung-Ming Hsiung, Jeng Chang, Pang-Hung Hsu, Tai-Chia Chiu, Chih-Ching Huang, &quot;Identification of Microalgae by Laser Desorption/Ionization Mass Spectrometry Coupled with Multiple Nanomatrices,&quot; Marine Biotechnology, Apr, 2016.</li>
<li>Ting-Ying Wu, Ping Kao, Chia-Lun Chang, Pang-Hung Hsu, Chang-Hung Chou, Ing-Feng Chang, &quot;Phosphoproteomic profiling of microsomal fractions in leaves of Cogon grass (Imperata cylindrica),&quot; Plant Omics Journal, Dec, 2015.</li>
<li>Po-Jen Chen, Jui-Yun Weng, Pang-Hung Hsu, Jin-Yuh Shew, Yi-Shuian Huang*, Wen-Hwa Lee*, &quot;NPGPx modulates CPEB2-controlled HIF-1&alpha; RNA translation in response to oxidative stress,&quot; Nucleic Acids Research, Oct, 2015.</li>
<li>Chiung-Yao Fang, Cheng-Huang Shen, Meilin Wang, Pei-Lain Chen, Michael W.Y. Chan, Pang-Hung Hsu*, Deching Chan*, &quot;Global profiling of histone modifications in the polyomavirus BK virion minichromosome,&quot; Virology, Sep, 2015.</li>
<li>Pang-Hung Hsu*, Pei-Chi Chiang, Chia-Hsun Liu, Ya-Wen Chang*, &quot;Characterization of Cell Wall Proteins in Saccharomyces cerevisiae Clinical Isolates Elucidates Hsp150p in Virulence,&quot; PLoS ONE, Aug, 2015.</li>
<li>Hsiu-Chuan Lin, Szu-Chi Ho,Yi-Yun Chen, Kay Hooi Khoo, Pang-Hung Hsu, Hsueh-Chi S. Yen*, &quot;CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding,&quot; Science, Jul, 2015.</li>
<li>I-Ting Chen, Pang-Hung Hsu, Wan-Ching Hsu, Nien-Jung Chen, Ping-Hui Tsenga, &quot;Polyubiquitination of Transforming Growth Factor &beta;-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation,&quot; Scientific Report, Jul, 2015.</li>
<li>Pang-Hung Hsu, Chien-Han Wei, Wen-Jung Lu, Fen Shen, Chorng-Liang Pan*, Hong-Ting Victor Lin*, &quot;Extracellular production of a novel endo-&beta;-agarase AgaA from Pseudomonas vesicularis MA103 that cleaves agarose into neoagarotetraose and neoagarohexaose,&quot; International Journal of Molecular Sciences, Mar, 2015.</li>
<li>&quot;Zih-Jie Shen; Pang-Hung Hsu; Yu-Tai Su; Chia-Wei Yang; Li Kao; Shun-Fu Tseng; Ming-Daw Tsai; Shu-Chun Teng&quot;, &quot;PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase,&quot; Nature Communication, Nov, 2014.</li>
<li>Szu-Wei Chang; Wei-Chen Liu; Kuan-Yu Liao; Yeou-Ping Tsao; Pang-Hung Hsu; Show-Li Chen, &quot;Phosphorylation of HPV-16 E2 at Serine 243 Enables Binding to Brd4 and Mitotic Chromosomes,&quot; PLoS ONE, Oct, 2014.</li>
<li>Hong-Ming Hsu; Yu Lee; Pang-Hung Hsu; Hsing-Wei Liu; Chien-Hsin Chu; Ya-Wen Chou; Yet-Ran Chen; Shu-Hui Chen; Jung-Hsiang Tai, &quot;Signal Transduction Triggered by Iron to Induce the Nuclear Importation of a Myb3 Transcription Factor in the Parasitic Protozoan Trichomonas vaginalis,&quot; The Journal of Biological Chemistry, Sep, 2014.</li>
<li>Lee, Marianne M.; Fekner, Tomasz; Lu, Jia; Heater, Bradley S.; Behrman, Edward J.; Zhang, Liwen; Hsu, Pang-Hung; Chan, Michael K., &quot;Pyrrolysine-Inspired Protein Cyclization,&quot; ChemBioChem, Aug, 2014.</li>
<li>Lin, Jer-Sheng; Wu, Hsin-Hui; Hsu, Pang-Hung; Ma, Lay-Sun; Pang, Yin-Yuin; Tsai, Ming-Daw; Lai, Erh-Min, &quot;Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens,&quot; PLoS Pathogen, Mar, 2014.</li>
<li>&quot;Shyu, Yu-Chiau; Lee, Tung-Liang; Chen, Xin; Hsu, Pang-Hung; Wen, Shau-Ching; Liaw, Yi-Wei; Lu, Chi-Huan; Hsu, Po-Yen; Lu, Mu-Jie; Hwang, Jaulang; Tsai, Ming-Daw; Hwang, Ming-Jing; Chen, Jim-Ray; Shen, Che-Kun James &quot;, &quot;Tight Regulation of a Timed Nuclear Import Wave of EKLF by PKCtheta and FOE during Pro-E to Baso-E Transition,&quot; Developmental cell, Feb, 2014.</li>
<li>&quot;Shen, Yu-Wei; Hsu, Pang-Hung; Unnikrishnan, Binesh; Li, Yu-Jia; Huang, Chih-Ching &quot;, &quot;Membrane-based assay for iodide ions based on anti-leaching of gold nanoparticles,&quot; ACS applied materials &amp; interfaces, Feb, 2014.</li>
<li>Unnikrishnan, Binesh; Wei, Shih-Chun; Chiu, Wei-Jane; Cang, Jinshun; Hsu, Pang-Hung*; Huang, Chih-Ching*, &quot;Nitrite ion-induced fluorescence quenching of luminescent BSA-Au25 nanoclusters: mechanism and application,&quot; Analyst, Feb, 2014.</li>
<li>&quot;Chu, Chi-Shuen; Lo, Pei-Wen; Yeh, Yi-Hsien; Hsu, Pang-Hung; Peng, Shih-Huan; Teng, Yu-Ching; Kang, Ming-Lun; Wong, Chi-Huey; Juan, Li-Jung &quot;, &quot;O-GlcNAcylation regulates EZH2 protein stability and function,&quot; Proceedings of the National Academy of Sciences of the United States of America, Jan, 2014.</li>
<li>Shih-Jhe Huang, Chia-Lun Chang, Po-Hsun Wang, Min-Chieh Tsai, Pang-Hung Hsu, Ing-Feng Chang, &quot;A type III ACC synthase, ACS7, is involved in root gravitropism in Arabidopsis thaliana,&quot; Journal of Experimental Botany, Nov, 2013.</li>
<li>Yang, Fu-Chia; Lin, Ya-Huei; Chen, Wei-Hao; Huang, Jing-Yi; Chang, Hsin-Yun; Su, Su-Hui; Wang, Hsiao-Ting; Chiang, Chun-Yi; Hsu, Pang-Hung; Tsai, Ming-Daw; Tan, Bertrand Chin-Ming; Lee, Sheng-Chung, &quot;Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells,&quot; The Journal of Biological Chemistry, Nov, 2013.</li>
<li>Shaohui Wang, Ying Li, Pang-Hung Hsu, Sou-Ying Lee, Yoon Kim, Eva Y.-H. P. Lee, &quot;Progesterone Receptor A Stability Is Mediated by Glycogen Synthase Kinase-3&beta; in the Brca1-deficient Mammary Gland,&quot; The Journal of Biological Chemistry, Sep, 2013.</li>
<li>Marianne M. Lee, Tomasz Fekner, Tsz-Ho Tang, Lin Wang, Aurora Ho-Yin Chan, Pang-Hung Hsu, Shannon W. Au, Michael K. Chan, &quot;A Click-and-Release Pyrrolysine Analogue,&quot; ChemBioChem, May, 2013.</li>
<li>Pei-Yu Chiang, Yu-Fang Shen, Yu-Lun Su, Ching-Han Kao, Nien-Yi Lin, Pang-Hung Hsu, Ming-Daw Tsai, Shun-Chang Wang, Geen-Dong Chang, Sheng-Chung Lee, Ching-Jin Chang, &quot;Phosphorylation of mRNA Decapping Protein Dcp1a by the ERK Signaling Pathway during Early Differentiation of 3T3-L1 Preadipocytes,&quot; PLoS One, May, 2013.</li>
<li>Jyun-Wei Jian, Wei-Chane Chiu, Huan-Tsung Chang, Pang-Hung Hsu* and Chih-Ching Huang*, &quot;Fibrinolysis and Thrombosis of Fibrinogen-Modified Gold Nanoparticles for Detection of Fibrinolytic-Related Proteins,&quot; Analytica Chimica Acta, Apr, 2013.</li>
<li>&quot;Fu-Chia Yang, Bertrand Chin-Ming Tan, Wei-Hao Chen , Ya-Huei Lin, Jing-Yi Huang, Hsin-Yun Chang, Hui-Yu Sun, Pang-Hung Hsu, Gunn-Guang Liou, James Shen , Ching-Jin Chang, Chau-Chung Han, Ming-Daw Tsai, and Sheng-Chung Lee&quot;, &quot;Reversible Acetylation Regulates Salt-Inducible Kinase (SIK2) and Its Function in Autophagy,&quot; The Journal of Biological Chemistry, Mar, 2013.</li>
<li>Yung-Lin Hsieh, Hong-Yi Kuo, Che-Chang Chang, Mandar T Naik, Pei-Hsin Liao, Chun-Chen Ho, Tien-Chi Huang, Jen-Chong Jeng, Pang-Hung Hsu, Ming-Daw Tsai, Tai-Huang Huang and Hsiu-Ming Shih, &quot;Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response,&quot; The EMBO Journal, Mar, 2013.</li>
<li>Po-Han Chen, Chia-I Lee, Yu-Tzu Weng, Woan-Yuh Tarn, Yeou-Ping Tsao, Ping-Chang Kuo, Pang-Hung Hsu, Chu-Wei Huang, Chiun-Sheng Huang, Hsiu-Hsiang Lee,June-Tai Wu, Show-Li Chen*, &quot;BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing,&quot; RNA, Feb, 2013.</li>
<li>Pei-Chi Wei, Yi-Hsuan Hsieh, Mei-I. Su, X.-J. Jiang, Pang-Hung Hsu, Wen-Ting Lo, Jui-Yun Weng, Yung-Ming Jeng, Ju-Ming Wang, Phang-lang Chen, Yi-Cheng Chang, Kuo-Fen Lee, Ming-Daw Tsai, Jin-Yuh Shew, Wen-Hwa Lee, &quot;Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease,&quot; Molecular Cell, Dec, 2012.</li>
<li>Chia-Chi Flora Huanga, Jui-Hung Wenga, Tong-You Wade Weia, Pei-Yu Gabriel Wu, Pang-Hung Hsu, Yu-Hou Chena, Shun-Chang Wang, Dongyan Qin, Chin-Chun Hung, Shui-Tsung Chen, Andrew H.-J. Wang, John Y.-J. Shyy and Ming-Daw Tsai, &quot;Intermolecular Binding between TIFA-FHA and TIFA-pT Mediates Tumor Necrosis Factor Alpha Stimulation and NF-&kappa;B Activation,&quot; Molecular and Cellular Biology, Jul, 2012.</li>
<li>I-Chen Peng, Zhen Chen, Wei Sun, Ying-Shiuan Li, Traci LaNai Marin, Pang-Hung Hsu, Mei-I Su, Xiaopei Cui, Songqin Pan, Christian Y. Lytle, David A. Johnson, Frank Blaeser, Talal Chatila, and John Y-J. Shyy, &quot;Glucagon regulates ACC activity in adipocytes through the CAMKK&beta;/AMPK pathway,&quot; American Journal of Physiology: Endocrinology and Metabolism, Jun, 2012.</li>
<li>Hsia-Yuan Ying, Shin-Tang Su, Pang-Hung Hsu, Che-Chang Chang, I-Ying Lin, Yu-Hsuan Tseng, Ming-Daw Tsai, Hsiu-Ming Shih, Kuo-I Lin, &quot;SUMOylation of Blimp-1 is critical for plasma cell differentiation,&quot; EMBO Reports, May, 2012.</li>
<li>Ing-Feng Chang, Jue-Liang Hsu, Pang-Hung Hsu, Wei-An Sheng, Shiuan-Jeng Lai, Cindy Lee, Chun-Wei Chen, Jen-Chieh Hsu, Shu-Ying Wang, Lan-Yu Wang, Ching-Chuan Chen, &quot;Comparative phosphoproteomic analysis of microsomal fractions of Arabidopsis thaliana and Oryza sativa subjected to high salinity,&quot; Plant Science, Apr, 2012.</li>
<li>Shih-Chun Wei, Pang-Hung Hsu, Yen-Fei Lee, Yang-Wei Lin, and Chih-Ching Huang, &quot;Selective Detection of Iodide and Cyanide Anions Using Gold-Nanoparticle-Based Fluorescent Probes,&quot; ACS Applied Materials and Interfaces, Apr, 2012.</li>
<li>Han-Yi Chou, Ting-Huang Wang, Sheng-Chung Lee, Pang-Hung Hsu, Ming-Daw Tsai, Chih-Ling Chang, Yung-Ming Jeng, &quot;Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis,&quot; Cell Cycle, Dec, 2011.</li>
<li>Pei-Lain Chen, Pang-Hung Hsu, Chiung-Yao Fang, Chi-Fang Chang, Wei-Chih Ou, Meilin Wang, Deching Chang, &quot;Phosphorylation of Ser-80 on VP1 and Ser-254 on VP2 are essential for human BK virus propagation in tissue culture,&quot; Journal of General Virology, Nov, 2011.</li>
<li>Yu-Fang Shen, Yu-Hou Chen, Shao-Ying Chu, Meng-I Lin, Hua-Ting Hsu, Pei-Yu Wu, Chao-Jung Wu, Hui-Wen Liu, Fu-Yang Lin, Gialih Lin, Pang-Hung Hsu, An-Suei Yang, Yih-Shyun E. Cheng, Ying-Ta Wu, Chi-Huey Wong, Ming-Daw Tsai, &quot;E339&hellip;R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors,&quot; Proceedings of the National Academy of Sciences of the United States of America, Oct, 2011.</li>
<li>Chi-Shuen Chu, Pang-Hung Hsu, Pei-Wen Lo, Elisabeth Scheer,Laszlo Tora, Hang-Jen Tsai, Ming-Daw Tsai, Li-Jung Juan, &quot;Protein Kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from miotic chromosome,&quot; The Journal of Biological Chemistry, Jul, 2011.</li>
<li>Chen-Yi Wang, Chia-Yin Hua, Hsiang-En Hsu, Chia-Ling Hsu, Hsin-Yi Tseng, Duncan E. Wright, Pang-Hung Hsu, Chih-Hung Jen, Chia-Yeh Lin, Meng-Ying Wu, Min-Daw Tsai, Cheng-Fu Kao, &quot;The C-Terminus of Histone H2B Is Involved in Chromatin Compaction Specifically at Telomeres, Independently of Its Monoubiquitylation at Lysine 123,&quot; PLoS One, Jul, 2011.</li>
<li>Connie Y. Tsai, Bryan Ngo, Anjali Tapadia, Pang-Hung Hsu, Guikai Wu, Wen-Hwa Lee, &quot;Aurora-A phosphorylates augmin complex component Hice1 at N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly,&quot; The Journal of Biological Chemistry, Jun, 2011.</li>
<li>Chung-Yi Liang, Pang-Hung Hsu, Dai-Fang Chou, Chao-Yu Pan, Long-Chi Wang, Wei-Chieh Huang, Ming-Daw Tsai, Wan-Sheng Lo*, &quot;The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1,&quot; Nucleic Acids Research, Feb, 2011.</li>
<li>Hua Xu*, Pang-Hung Hsu*, Liwen Zhang, Ming-Daw Tsai, Michael A. Freitas, &quot;A Database Search Algorithm for Identification of Intact Cross-Links in Proteins and Peptides Using Tandem Mass Spectrometry,&quot; Journal of Proteome Research, Jul, 2010.</li>
<li>Fang, Chiung-Yao, Hsiang-Ying Chen, Meilin Wang, Pei-Lain Chen, Chi-Fang Chang, Li-Sheng Chen, Cheng-Huang Shen, Wei-Chih Ou, Li-Jung Juan, Ming-Daw Tsai, Pang-Hung Hsu*, Deching Chang*, &quot;Global Analysis of Modifications of the Human BK Virus Structural Proteins by LC-MS/MS,&quot; Virology, Apr, 2010.</li>
<li>Tung-Liang Lee, Yu-Chiau Shyu, Pang-Hung Hsu, Chiung-Wen Chang, Shau-Ching Wen, Wei-Yuan Hsiao, Ming-Daw Tsai, and Che-Kun J, &quot;JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells,&quot; Proceedings of the National Academy of Sciences of the United States of America, Jan, 2010.</li>
<li>Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Yi Fu, Yi Zhu, Kathryn DeFea, Songqin Pan, Ming-Daw Tsai, John Y-J, &quot;AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser-633,&quot; Circulation Research, Feb, 2009.</li>
<li>Xiaodan Su, Naduparambil K. Jacob, Ravindra Amunugama, Pang-Hung Hsu, Richard Fishel, Michael A. Freitas, &quot;Enrichment and characterization of histones by two-dimensional hydroxyapatite/reversed-phase liquid chromatography&ndash;mass spectrometry,&quot; Analytical Biochemistry, Jan, 2009.</li>
<li>Shengjiang Tu, Esther M. M. Bulloch, Lanhao Yang, Chen Ren, Wei-Chieh Huang, Pang-Hung Hsu, Chein-Hung Chen, Chung-Lin Liao,, &quot;Identification of Histone Demethylases in Sacchromyces cerevisiae,&quot; Journal of Biological Chemistry, May, 2007.</li>
<li>Chen Ren, Shujun Liu, Kalpana Ghoshal, Pang-Hung Hsu, Samson T. Jacob, Guido Marcucci, Michael A. Freitas, &quot;Simultaneous metabolic labeling of cells with multiple amino acids: localization and dynamics of histone acetylation and methylation,&quot; Proteomics: Clinical Applications, Jan, 2007.</li>
<li>Pang-Hung Hsu, Patrick G. Hatcher, &quot;Covalent Coupling of Peptides to Humic Acids: Structural Effects Investigated by 2D NMR Spectroscopy,&quot; Organic Geochemistry, Dec, 2006.</li>
<li>Pang-Hung Hsu, Patrick G. Hatcher, &quot;New Evidence For Covalent Coupling Of Peptides To Humic Acids Based On 2D NMR Spectroscopy: A Means For Preservation,&quot; Geochimica et Cosmochimica Acta, Sep, 2005.</li>
</ol>
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