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林秀美 教授

姓 　 　 名：林秀美 老師實驗室
英 文 姓 名：Hsiu-Mei Lin
研 究 專 長：奈米生物科技、智慧型藥物輸送、生醫材料、奈米藥物輸送、生醫奈米影像、螢光粉、綠色化學、材料化學、海洋活性物質、海洋生物技術開發、應用化妝品
電 子 信 箱：hmlin@mail.ntou.edu.tw
研究室位置：綜合二館302b-2(辦公室); 302b-3(研究室)
研究室電話：2462-2192 ext. 5562(辦公室); 5563(研究室)
 
主要授課課程：
  • 有機化學
  • 分子生物學
 
學經歷：
  • 國立台灣大學 / 化學研究所 / 博士
  • 國立臺灣海洋大學生命科學暨生物科技學系 / 教授
  • 國立台灣海洋大學生命科學系 / 副教授
  • 國立台灣海洋大學生命科學系 / 助理教授
 
研究項目簡介：
  1. 智慧型藥物傳遞系統：中孔洞二氧化矽奈米粒子，藉由材料表面的官能化，賦予標靶、調控釋放功能；摻雜具有光學以及磁性元素使具有可追蹤特性，達到同時具有特定目標控制釋放且可以非侵入式檢測追蹤之多功能智慧型藥物傳遞系統。
  2. 多功能骨修復系統：中孔洞二氧化矽生物活性玻璃，材料中含有鈣、磷成份，可作為骨修復之材料；延續上述中孔洞二氧化矽材料本身所具有之優勢，進一步成為具有特定目標藥物治療且可以非侵入式檢測追蹤之多功能可傳遞藥物之骨修復系統。
  3. 生物資源/廢棄物轉化之功能性材料：生活周遭常見之物質，如貝殼富含高比例之碳酸鈣、矽藻本身具有的特殊圖案之二氧化矽孔洞結構、稻殼中高含量之二氧化矽，可利用純化的過程，進一步改質成為多功能之再生材料，賦予資源能夠更加有效利用的價值。
 
實驗室常用技術：

中孔洞二氧化矽材料之合成、修飾與鑑定(XRD、BET、TGA、FT-IR、SEM、TEM、SQUID、ICP等)、細胞培養、光譜儀(UV-vis、PL/PLE等)、細胞/動物顯影(Confocal/IVIS)、核磁共振(MRI)等。

 

  1. Hsiu-Mei Lin*, Chih-Hwa Chen, Fu-Yin Hsu, Zhi-Yuan Wu, Pei-Chun Wong (2023, May). Biosilica source converted into mesoporous bioactive glass implanted for tendon bone healing. Journal of the Chinese Chemical Society, 70(5), 1048-1054. 
  2. Yu-Ya Huang, Zui-Harng Lee, Kai-Chi Chang, Zhi-Yuan Wu, Cheng-Chang Lee, Min-Hsuan Tsou and Hsiu-Mei Lin* (2023, May). Mesoporous silica nanoparticles with dualtargeting agricultural sources for enhanced cancer treatment via tritherapy. RSC Advances, 13, 19079. 
  3. Kai-Chi Chang, Li-Wei Lee, Hsiu-Mei Lin, Chih-Feng Yen, Chih-Min Wang and Jing-Yun Wu (2022, Oct). Hetero-interpenetrating porous coordination polymers. Dalton Transactions, 51(18), 7025-7034.  
  4. Min-Hsuan Tsou, Cheng-Chang Lee, Zhi-Yuan Wu, Zui-Harng Lee, Hsiu-Mei Lin* (2022, Sep). Bioactivity of crude fucoidan extracted from Sargassum ilicifolium (Turner) C. Agardh. Scientific Reports, 12, 15916. 
  5. Zui‑Harng Lee, Meng‑Feng Lee, Jung‑Huang Chen, Min‑Hsuan Tsou, Zhi‑Yuan Wu, Cheng‑Zhang Lee, Yu‑Ya Huang, Showe‑Mei Lin, Hsiu‑Mei Lin* (2022, Jun). Fucoidan with three functions extracted from Sargassum aquifolium integrated rice‑husk synthesis dual‑imaging mesoporous silica nanoparticle. Journal of Nanobiotechnology, 20(1), 298. 
  6. Zhi-Yuan Wu, Zui-Harng Lee,Yu-Ya Huang, Min-Hsuan Tsou, Hsiu-Mei Lin* (2022, Jan). Drug delivery system with dual imaging and dual response control drug release functions for chemo-photodynamic synergistic therapy. Journal of Inorganic Biochemistry, 230, 111717. 
  7. Min-Hsuan Tsou, Cheng-ChangLee, Zhi-Yuan Wu, Zui-Harng Lee, Hsiu-Mei Lin* (2021, Oct). Mesoporous silica nanoparticles with fluorescent and magnetic dual-imaging properties to deliver fucoidan. International Journal of Biological Macromolecules, 180, 870-878. 
  8. Ying Li, Han-Ying Li, Kai-Chi Chang Hsiu-Mei Lin and Chih-Min Wang (2021, Aug). Recent developments in organic-inorganic hybrid metal phosphates and phosphites. Dalton Transactions, 50(29), 10014-10019.  
  9. Tzu-Hsuan Lo, Zhi-Yuan Wu, Shiow-Yi Chen, Fan-Yi Meng, Pi-Tai Chou, Chih-Min Wang, Hsiu-Mei Lin* (2021, Jan). Curcumin-loaded mesoporous silica nanoparticles with dual-imaging and temperature control inhibits the infection of Zika virus. Microporous and Mesoporous Materials, 314, 110886. 
  10. Chuan Chen, Chia-Fang Hsieh, Hsiu-Mei Lin, Ying-Feng Hsu, Jye-Shane Yang and Chih-Min Wang (2019, Jul). A dual fluorescent/phosphorescent zincophosphite with interesting water adsorption and structural transformation properties. Dalton Transactions, 48(38), 14294-14298. 
  11. Zhi-Yuan Wu, Cheng-Chang Lee, Hsiu-Mei Lin* (2019, May). Hyaluronidase-Responsive Mesoporous Silica Nanoparticles with Dual-Imaging and Dual-Target Function. Cancers, 11(5), 697. 
  12. Wei-Ju Lin, Yu-Ming Liao, Hsia-Yu Lin, Golam Haider, Shih-Yao Lin, Wei-Cheng Liao, Ruei-Ti Wei, Packiyaraj Perumal, Tsung-Yuan Chang, Chang-Yang Tseng, Lo, Yan-Shawn Lo, Hsiu-Mei Lin, Tung-Wei Shih, Jiang-Shiou Hwang, Tai-Yuan Lin, Yang-Fang Chen (2018, Nov). All-marine based random lasers. Organic Electronics, 62, 209-215. 
  13. Shiao-Wen Tsai, Wen-Xin Yu, Pai-An Hwang, Sheng-Siang Huang, Hsiu-Mei Lin, Yu-Wei Hsu, and Fu-Yin Hsu (2018, Aug). Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO(3) Nanofibers with a Mesoporous Structure as Drug Delivery Carriers.. Pharmaceutics, 10 (4), 179.
  14. Chih-Min Wang, Ming-Feng Pan, Yong-Jie Lin, Mei-Ying Chung, Yuh-Sheng Wen, Yung Chang, Hsiu-Mei Lin, and Todd Hsu (2018, May). A Series of Organic-Inorganic Hybrid Zinc Phosphites Containing Extra-Large Channels. Inorganic Chemistry, 57 (5), 2390-2393.
  15. Kai-Chi Chang, Chan-Yu Chen, Tzu-Pin Lin, Po-Jen Ku, Chun-Lin Chen, Chih-Ming Wang, Hsiu-Mei Lin, Mei-Chun Tseng, Ashutosh S. Singha and Shih-Sheng Sun (2018, Jan). Journal of the Chinese Chemical Society. Journal of the Chinese Chemical Society, 65 (1), 141-148. 
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