鄒文雄 教授兼系主任
姓 名：鄒文雄 老師實驗室
英 文 姓 名：Wen-Shyong Tzou
研 究 專 長：基因體資訊分析、生物資訊
主要授課課程：
- 程式設計與資料處理
- Python與人工智慧
- 使用Linux指令分析基因體資訊
- 使用R指令分析基因體資訊
- R語言與資料分析
- 基因體學與機器學習
學經歷：
- 學士：交通大學電子物理系 1988
- 碩士：清華大學生命科學所 1990
- 博士：國防醫學院生命科學所 1998
- 博士後研究：中央研究院分子生物研究所 1999
- 副研究員：法國科學研究國家中心生物物理化學研究所 2000
- 經理：台灣基因科技公司 2001
- 助理教授：高雄醫學大學 生物科技系 2002
- 助理教授：臺灣海洋大學生物科技所 2004
- 副教授：臺灣海洋大學 生物科技所 2007
- 教授：臺灣海洋大學 生命科學暨生物科技學系 2014
- 教授：美國維吉尼亞大學訪問教授 2016
研究項目簡介：
- 人類基因突變對蛋白質的結構影響與癌症突變負擔途徑探討(Tumor Mutation Pathway Burden)：
Alphafold已經可以預測蛋白質結構，本研究針對基因突變可能影響的途徑，此途徑中的蛋白質突變的負擔生物資訊計算與評估，以作為可能罹患癌症的預測模型。 - 利用機器學習與可解釋人工智慧發掘台灣常見癌症的指標與關鍵基因
- 蛋白質結構模擬與蛋白質工程設計分解塑膠的酵素，以解決塑膠微粒的海洋汙染
- 以總體基因體學分析基隆漁港港區海水與底泥的微生物群
- 分析全球海洋的基因表現與環境參數關係:
探討浮游微生物的基因表現與各環境參數的相關性，推論浮游微生物的環境適應。
期刊論文 : 科技部研究人才查詢-著作目錄
16. Chi-Yu Shih, Shiow-Yi Chen, Chun-Ru Hsu, Ching-Hsiang Chin, Wei-Chih Chiu, Mei-Hung Chang, Lee-Kuo Kang, Cing-Han Yang, Tun-Wen Pai, Chin-Hwa Hu, Pang-Hung Hsu*, Wen-Shyong Tzou* (2023, Jun). Distinctive microbial community and genome structure in coastal seawater from a human-made port
and nearby offshore island in northern Taiwan facing the Northwestern Pacific Ocean. PLoS ONE, 18(6):e0284022.
and nearby offshore island in northern Taiwan facing the Northwestern Pacific Ocean. PLoS ONE, 18(6):e0284022.
15. H.-H. Chen, C.-J. Lin, A. Anand, H.-J. Lin, H.-Y. Lin, J.-Y. Mao, P.-H. Wang, Y. J. Tseng, W.-S. Tzou, C.-C. Huang* and R. Y. L. Wang* (2022, Jun). Development of Antiviral Carbon Quantum Dots that Target the Japanese Encephalitis Virus Envelope Protein. J. Biol. Chem, 298, 101957.
14. Kuo-Sheng Hung*, Shiow-Yi Chen, Pang-Hung Hsu, Bo-An Lin, Chin-Hua Hu, Cing-Han Yang, Tun-Wen Pai, Wen-Shyong Tzou, Hsin-Yu Chung* (2022, Jun). Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases. Genes, 13(6):1096. nstc 104-2321-B-019-005-MY3.
13. Hsin-Yu Chung, Bo-An Lin, Yi-Xuan Lin, Chen-Wei Chang, Wen-Shyong Tzou, Tun-Wen Pei, Chin-Hwa Hu (2021, Oct). Meis1, Hif1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis. FASEB Journal, 35(10):e21915.
12. Chun-cheng Liu, Tao-chuan Shih, Tun-wen Pai, Chin-hwa Hu, and Wen-shyong Tzou (2021, Jul). Enhanced Over-Representation Analysis for the Differential Regulation of Birc5a and HIF2α-Knockdown Approaches. Journal of Computational Biology, 28(7):674-686.
11. Wen-Shyong Tzou*,Chung-Hao Li, Pang-Hung Hsu,Tun-Wen Pai, Chin-Hwa Hu (2021, Jan). Microsecond-Timescale Conformational Dynamics Reveals the Flexibility and Communication Pathway of the KIT Extracellular Domain in Complex with Stem Cell Factor. Journal of Biotechnology and Bioengineering, 5(1):pp1-12.
10. Jing Hou, Heping Zheng*, Wen‐Shyong Tzou, David R. Cooper, Maksymilian Chruszcz, Mahendra D. Chordia, Keehwan Kwon, Marek Grabowski and Wladek Minor* (2018, Aug). Differences in substrate specificity of V. cholerae FabH enzymes suggest new approaches for the development of novel antibiotics and biofuels. FEBS Journal, 285(15):2900-2921.
9. Kuo-Sheng Hung, Chung-Chi Hsiao, Tun-Wen Pai*, Chin-Hwa Hu, Wen-Shyong Tzou, Wen-Der Wang and Yet-Ran Chen (2018, Apr). Functional enrichment analysis based on long noncoding RNA associations. BMC Systems Biology, 12(Suppl 4):45.
8. Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang* (2016, Oct). Ultrastrong Trapping of VEGF by Graphene Oxide: Anti-angiogenesis Application. Biomaterials, 109:12-22.
7. Chi-Fu Chou, Han-Jia Lin, Chih-Yu Tsai, Tzung-Yi Lin, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Tun-Wen Pai, Chin-Hwa Hu, and Wen-Shyong Tzou* (2015, Jun). Hypoxia-inducible factor 2-alpha participates in the regulation of intersegmental vessels angiogenesis and neuromast deposition. Journal of Marine Science and Technology, 24(2):347-358.
6. Wen Sing Liang, Tsuei Yun Fang, Hong Ting Lin, Tristan C. Liu, Wen Jung Lu, Wen Shyong Tzou, Shye Jye Tang, Fu Pang Lin, Shiu Mei Liu, Chorng Liang Pan. (2015). Cloning, expression, and characterization of Pseudomonas vesicularis MA103 β 1,3 xylanase in Escherichia coli ClearColi BL21(DE3). Fish Science, 81:1135–1143.
5. Tzung-Yi Lin, Chi-Fu Chou1, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li,Jen-Leih Wu, Han-Jia Lin, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou (2014, Jul). Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo. PLoS ONE, 9(7): e101980.
4. Tzou WS*, Lo YT, Pai TW, Hu CH, Li CH. (2014, May). Stochastic Simulation of Notch Signaling Reveals Novel Factors That Mediate the Differentiation of Neural Stem Cells. Journal of Computational Biology, 21(7):548-67.
3. Tzou WS*, Chu Y, Lin TY, Hu CH, Pai TW, Liu HF, Lin HJ, Cases I, Rojas A, Sanchez M, You ZY, Hsu MW. (2014, Jan). Molecular Evolution of Multiple-Level Control of Heme Biosynthesis Pathway in Animal Kingdom. PLoS ONE, 9(1):e86718.
2. Chang CT, Chung HY, Su HT, Tseng HP, Tzou WS, Hu CH. (2013, Jul). Regulation of zebrafish CYP3A65 transcription by AHR2. Toxicology and Applied Pharmacology, 270(2):174-84.
1. Chung HY, Chang CT, Young HW, Hu SP, Tzou WS, Hu CH. (2013, May). Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway.. Neurotoxicology and Teratology , 38:92-103.
14. Kuo-Sheng Hung*, Shiow-Yi Chen, Pang-Hung Hsu, Bo-An Lin, Chin-Hua Hu, Cing-Han Yang, Tun-Wen Pai, Wen-Shyong Tzou, Hsin-Yu Chung* (2022, Jun). Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases. Genes, 13(6):1096. nstc 104-2321-B-019-005-MY3.
13. Hsin-Yu Chung, Bo-An Lin, Yi-Xuan Lin, Chen-Wei Chang, Wen-Shyong Tzou, Tun-Wen Pei, Chin-Hwa Hu (2021, Oct). Meis1, Hif1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis. FASEB Journal, 35(10):e21915.
12. Chun-cheng Liu, Tao-chuan Shih, Tun-wen Pai, Chin-hwa Hu, and Wen-shyong Tzou (2021, Jul). Enhanced Over-Representation Analysis for the Differential Regulation of Birc5a and HIF2α-Knockdown Approaches. Journal of Computational Biology, 28(7):674-686.
11. Wen-Shyong Tzou*,Chung-Hao Li, Pang-Hung Hsu,Tun-Wen Pai, Chin-Hwa Hu (2021, Jan). Microsecond-Timescale Conformational Dynamics Reveals the Flexibility and Communication Pathway of the KIT Extracellular Domain in Complex with Stem Cell Factor. Journal of Biotechnology and Bioengineering, 5(1):pp1-12.
10. Jing Hou, Heping Zheng*, Wen‐Shyong Tzou, David R. Cooper, Maksymilian Chruszcz, Mahendra D. Chordia, Keehwan Kwon, Marek Grabowski and Wladek Minor* (2018, Aug). Differences in substrate specificity of V. cholerae FabH enzymes suggest new approaches for the development of novel antibiotics and biofuels. FEBS Journal, 285(15):2900-2921.
9. Kuo-Sheng Hung, Chung-Chi Hsiao, Tun-Wen Pai*, Chin-Hwa Hu, Wen-Shyong Tzou, Wen-Der Wang and Yet-Ran Chen (2018, Apr). Functional enrichment analysis based on long noncoding RNA associations. BMC Systems Biology, 12(Suppl 4):45.
8. Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang* (2016, Oct). Ultrastrong Trapping of VEGF by Graphene Oxide: Anti-angiogenesis Application. Biomaterials, 109:12-22.
7. Chi-Fu Chou, Han-Jia Lin, Chih-Yu Tsai, Tzung-Yi Lin, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Tun-Wen Pai, Chin-Hwa Hu, and Wen-Shyong Tzou* (2015, Jun). Hypoxia-inducible factor 2-alpha participates in the regulation of intersegmental vessels angiogenesis and neuromast deposition. Journal of Marine Science and Technology, 24(2):347-358.
6. Wen Sing Liang, Tsuei Yun Fang, Hong Ting Lin, Tristan C. Liu, Wen Jung Lu, Wen Shyong Tzou, Shye Jye Tang, Fu Pang Lin, Shiu Mei Liu, Chorng Liang Pan. (2015). Cloning, expression, and characterization of Pseudomonas vesicularis MA103 β 1,3 xylanase in Escherichia coli ClearColi BL21(DE3). Fish Science, 81:1135–1143.
5. Tzung-Yi Lin, Chi-Fu Chou1, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li,Jen-Leih Wu, Han-Jia Lin, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou (2014, Jul). Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo. PLoS ONE, 9(7): e101980.
4. Tzou WS*, Lo YT, Pai TW, Hu CH, Li CH. (2014, May). Stochastic Simulation of Notch Signaling Reveals Novel Factors That Mediate the Differentiation of Neural Stem Cells. Journal of Computational Biology, 21(7):548-67.
3. Tzou WS*, Chu Y, Lin TY, Hu CH, Pai TW, Liu HF, Lin HJ, Cases I, Rojas A, Sanchez M, You ZY, Hsu MW. (2014, Jan). Molecular Evolution of Multiple-Level Control of Heme Biosynthesis Pathway in Animal Kingdom. PLoS ONE, 9(1):e86718.
2. Chang CT, Chung HY, Su HT, Tseng HP, Tzou WS, Hu CH. (2013, Jul). Regulation of zebrafish CYP3A65 transcription by AHR2. Toxicology and Applied Pharmacology, 270(2):174-84.
1. Chung HY, Chang CT, Young HW, Hu SP, Tzou WS, Hu CH. (2013, May). Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway.. Neurotoxicology and Teratology , 38:92-103.